|
Vascular Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
The lead SNP at the 9p21 locus (rs4977574) was associated with all four vascular diseases (P < 4 × 10(-3)), illustrating the functional pleiotropy of this locus.
|
23828831 |
2013 |
|
Psoriasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The A allele of the rs4977574 had a protective effect against psoriasis (OR (95% CI) = 0.63 (0.49-0.81), adjusted P value = 0.001).
|
31812071 |
2020 |
|
Pseudocholinesterase Measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies.
|
21239051 |
2011 |
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
rs4977574 on chromosome 9p21 was genotyped in 24 777 subjects from the Malmö Diet and Cancer study who were free from CVD prior to the baseline examination.
|
23480785 |
2013 |
|
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
BEFREE |
One marker, rs6922269, in MTHFD1L was significantly protective against MI (OR=0.68, p=0.0035), while the variant rs4977574 in CDKN2A-CDKN2B was significantly associated with MI (OR=1.33, p=0.0086).
|
22216278 |
2011 |
|
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
GWASCAT |
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
|
19198609 |
2009 |
|
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
BEFREE |
Comparisons of allele frequencies by the χ(2) test revealed that rs9369640 of the phosphatase and actin regulator 1 gene (PHACTR1, FDR=0.0007), rs4977574 of the CDKN2B antisense RNA 1 gene (CDKN2B-AS1, FDR=0.0038), rs264 of the lipoprotein lipase gene (LPL, FDR=0.0061), rs599839 of the proline/serine-rich coiled-coil 1 gene (PSRC1, FDR=0.0118), rs9319428 of the fms-related tyrosine kinase 1 gene (FLT1, FDR=0.0118) and rs12413409 of the cyclin and CBS domain divalent metal cation transport mediator 2 gene (CNNM2, FDR=0.0300) were significantly associated with MI.
|
25738804 |
2015 |
|
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
BEFREE |
Four SNPs, rs4977574_A [0.56(0.50-0.63); p < 0.0001], rs10757274_A [0.87(0.77-0.97); p = 0.014], rs10738607_A [0.89(0.80-1.00); p = 0.043] and rs1333045_T [0.54(0.48-0.61); p < 0.0001] residing on the CDKN2B gene were significantly associated with CAD following multivariate adjustments for MI, HTN and DM, while four others were weakly associated with the disease.
|
29894795 |
2018 |
|
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
BEFREE |
The rs4977574 with G allele may confer to a higher risk of CAD, especially MI.
|
30278588 |
2018 |
|
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
BEFREE |
Besides the CAD/MI SNP at 9p21 (rs4977574, P = 3.1 × 10(-10)), two additional loci at ADAMTS7 (rs3825807, P = 6.5 × 10(-6)) and at PHACTR1 (rs12526453, P = 1.0 × 10(-3)) show a nominally significant association with coronary artery calcification with MI/CAD risk alleles increasing the degree of arterial calcification.
|
23561647 |
2013 |
|
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
GWASDB |
A common variant on chromosome 9p21 affects the risk of myocardial infarction.
|
17478679 |
2007 |
|
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
BEFREE |
PCR-RFLP revealed that the frequency of rs4977574, the MI-associated allele (G), was 56.8% (25/44) in patients with MI and 33.9% (9.5/28) in controls; the frequency of rs4977574 in patients with MI was significantly higher compared to controls (P = 0.027).
|
23856978 |
2013 |
|
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
GWASDB |
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
|
19198609 |
2009 |
|
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
BEFREE |
We showed a significant interaction between SSB intake and one of the 3 variants (i.e., rs4977574) on MI risk.
|
26961926 |
2016 |
|
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
BEFREE |
After age, sex, and BMI adjustment, we observed the SNPs rs12190287, rs12413409, rs1412444, rs1746048 and rs4977574, were significantly associated with MI in additive models and rs12190287, rs12413409, rs4977574 were significantly associated with phenotypes of MI at the same time.
|
24475106 |
2014 |
|
Multiple Sclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, haplotype analysis (rs1333045, rs1333048, rs4977574, and rs10757278 respectively) demonstrated protective effect of CCGG and TAAA haplotypes against MS (P values of 0.043 and 0.0026 respectively).
|
29713948 |
2018 |
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
rs4977574 on chromosome 9p21 was genotyped in 24 777 subjects from the Malmö Diet and Cancer study who were free from CVD prior to the baseline examination.
|
23480785 |
2013 |
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addi- tion, among all observed haplotypes (with SNP order of rs1333045, rs1333048 rs4977574 and rs10757278), four haplotypes were shown to be associated with breast cancer risk.
|
28580310 |
2017 |
|
Major Depressive Disorder
|
|
0.700 |
GeneticVariation
|
GWASDB |
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
|
23377640 |
2013 |
|
Ischemic stroke
|
|
0.020 |
GeneticVariation
|
BEFREE |
The interactions of rs1333040-rs1333042 on the risk of CHD and IS were relatively strong, whereas the interactions of rs1333040-rs1333042-rs2066715 and rs1333040-rs1333042-rs2066715-rs2740483 on the risk of CHD, and rs1333040-rs1333042-rs4977574 and rs1333040-rs1333042-rs4977574-rs2740483 on the risk of IS were relatively weak.
|
27096864 |
2016 |
|
Ischemic stroke
|
|
0.020 |
GeneticVariation
|
BEFREE |
SNP rs4977574 on chromosome 9p21.3 was associated with overall IS [odds ratio (OR) = 1.12; 95% confidence interval (CI): 1.04-1.20; P = 0.002] as well as LVD (OR = 1.36; 95% CI: 1.13-1.64; P = 0.001).
|
23631657 |
2013 |
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings suggest that the GG genotype of the CDKN2B-AS1 gene variant rs4977574, which has been previously associated with an increased CAD risk, is also associated with a decreased susceptibility to the development of hypertension.
|
29791233 |
2018 |
|
Heart Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Correlation Between 9p21 Chromosome rs4977574 Polymorphism Genotypes and the Development of Coronary Artery Heart Disease.
|
27240780 |
2017 |
|
Glioma
|
|
0.700 |
GeneticVariation
|
GWASDB |
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
|
21531791 |
2011 |
|
Glaucoma, Open-Angle
|
|
0.700 |
GeneticVariation
|
GWASDB |
Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma.
|
22570617 |
2012 |